High Lib mRNA Expression in Breast Carcinomas
نویسندگان
چکیده
منابع مشابه
High lib mRNA expression in breast carcinomas.
Lib, first identified as a novel beta-amyloid responsive gene in rat astrocytes, has an extracellular domain of 15 leucine-rich repeats (LRRs) followed by a transmembrane domain and a short cytoplasmic region. It is a distinctly inducible gene and is thought to play a key role in inflammatory states via the LRR extracellular motif, an ideal structural framework for protein-protein and protein-m...
متن کاملThe mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
BACKGROUND: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation. hTERT (human telomerase reverse transcriptase) is the rate-limiting determinant of telomerase reactivation. Telomerase has been associated with negative prognostic indicators in some studies. The present study aims to detect...
متن کاملHigh expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas.
BACKGROUND Cancer stem cells (CSC) have been described in a variety of malignancies, including breast carcinomas. Among several markers, aldehyde dehydrogenase 1 (ALDH1) has been identified as reliable for breast cancer stem cells. Knockdown of BRCA1 in primary breast epithelial cells leads to an increase in cells expressing ALDH1. METHODS We examined 127 breast carcinomas for expression of A...
متن کاملHigh-frequency deregulated expression of Wnt signaling pathway members in breast carcinomas
Purpose Breast carcinoma is the most common malignancy and leading cause of cancer-related deaths in women worldwide including Saudi Arabia. Breast cancer in Saudi women develops at a much early age with median age of onset of 49 years compared to 62 years observed in patients from USA. Aberrations in wingless and integration site growth factor (Wnt) signaling pathway have been pathologically i...
متن کاملIn situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas.
PURPOSE Blockade of the PD-1/PD-L1 axis emerged as a promising new therapeutic option for cancer that has resulted in lasting responses in metastatic renal, lung carcinomas, and melanomas. Tumor PD-L1 protein expression may predict response to drugs targeting this pathway. Measurement of PD-L1 protein is limited by the lack of standardized immunohistochemical methods and variable performance of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: DNA Research
سال: 2004
ISSN: 1340-2838
DOI: 10.1093/dnares/11.3.199